{"id":5384,"date":"2022-11-04T13:19:28","date_gmt":"2022-11-04T12:19:28","guid":{"rendered":"https:\/\/www.hartwigmedicalfoundation.nl\/?post_type=datarequests&#038;p=5384"},"modified":"2022-11-04T13:19:28","modified_gmt":"2022-11-04T12:19:28","slug":"dr-214-genomic-landscape-of-tumor-sensitivity-and-resistance-to-anti-cancer-drugs-in-colorectal-cancer-patients","status":"publish","type":"datarequests","link":"https:\/\/www.hartwigmedicalfoundation.nl\/en\/datarequests\/dr-214-genomic-landscape-of-tumor-sensitivity-and-resistance-to-anti-cancer-drugs-in-colorectal-cancer-patients\/","title":{"rendered":"DR-214 Genomic landscape of tumor sensitivity and resistance to anti-cancer drugs in colorectal cancer patients"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Colorectal cancer (CRC) ranks as the second most lethal cancer and the third most prevalent malignant tumor worldwide. Despite of continuous\u00a0development of a new targeted therapies and well defined molecular targets of potential sensitivity, the mechanisms associated with resistance events are poorly understood. Therefore, we will perform whole-genome sequencing data analyses on CRC patients genomes downloaded from Hartwig Medical Foundation and will identify a set of individual genomic features, underlying tumor drug sensitivity and\/or resistance. Obtained data will be used to develop a clinical predictor that will help patient stratification toward anti-cancer therapies, improving long-term clinical outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pawel Zawadzki, Adam Mickiewicz University in Pozna\u0144, Poland<\/p>\n","protected":false},"author":3,"featured_media":0,"template":"","request_years":[99],"class_list":["post-5384","datarequests","type-datarequests","status-publish","hentry","request_years-99"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>DR-214 Genomic landscape of tumor sensitivity and resistance to anti-cancer drugs in colorectal cancer patients - Hartwig Medical Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hartwigmedicalfoundation.nl\/en\/datarequests\/dr-214-genomic-landscape-of-tumor-sensitivity-and-resistance-to-anti-cancer-drugs-in-colorectal-cancer-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DR-214 Genomic landscape of tumor sensitivity and resistance to anti-cancer drugs in colorectal cancer patients - Hartwig Medical Foundation\" \/>\n<meta property=\"og:description\" content=\"Colorectal cancer (CRC) ranks as the second most lethal cancer and the third most prevalent malignant tumor worldwide. 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