{"id":5385,"date":"2022-11-04T13:21:33","date_gmt":"2022-11-04T12:21:33","guid":{"rendered":"https:\/\/www.hartwigmedicalfoundation.nl\/?post_type=datarequests&#038;p=5385"},"modified":"2022-11-04T13:21:33","modified_gmt":"2022-11-04T12:21:33","slug":"dr-288-the-molecular-profile-of-lynch-syndrome-associated-carcinomas","status":"publish","type":"datarequests","link":"https:\/\/www.hartwigmedicalfoundation.nl\/en\/datarequests\/dr-288-the-molecular-profile-of-lynch-syndrome-associated-carcinomas\/","title":{"rendered":"DR-288 The Molecular Profile of Lynch Syndrome-Associated Carcinomas"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Patients with Lynch Syndrome (LS) carry a mutation in\u00a0<em>MLH1, MSH2 (EPCAM), MSH6\u00a0<\/em>or\u00a0<em>PMS2<\/em>\u00a0and as a result have a genetic predisposition to develop colorectal cancer and endometrial cancer. Recent studies demonstrated that the clinical presentation of LS patients varies depending on which of these genes is affected, though the underlying mechanisms are incompletely understood. By analyzing the DNA of tumors of LS patients, we aim to identify and describe the pathogenic pathways responsible for this clinical variation, with the ultimate goal to develop subgroup-specific guidelines for the diagnosis, surveillance and treatment of patients with LS.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Maartje Nielsen, Leiden University Medical Center, the Netherlands<\/p>\n","protected":false},"author":3,"featured_media":0,"template":"","request_years":[99],"class_list":["post-5385","datarequests","type-datarequests","status-publish","hentry","request_years-99"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>DR-288 The Molecular Profile of Lynch Syndrome-Associated Carcinomas - Hartwig Medical Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hartwigmedicalfoundation.nl\/en\/datarequests\/dr-288-the-molecular-profile-of-lynch-syndrome-associated-carcinomas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DR-288 The Molecular Profile of Lynch Syndrome-Associated Carcinomas - 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