{"id":2350,"date":"2021-11-04T15:07:55","date_gmt":"2021-11-04T14:07:55","guid":{"rendered":"https:\/\/www.hartwigmedicalfoundation.nl\/pto\/"},"modified":"2022-02-21T14:20:39","modified_gmt":"2022-02-21T13:20:39","slug":"pto","status":"publish","type":"page","link":"https:\/\/www.hartwigmedicalfoundation.nl\/en\/pto\/","title":{"rendered":"Cancer of Unknown Primary\u00a0"},"content":{"rendered":"\n
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Each year, more than 1,500 people are diagnosed with CUP (Cancer of Unknown Primary). Half of these die within a few months of their first visit to hospital.\u00a0<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Right diagnosis\u00a0<\/h2>\n\n\n\n

CUP metastases are sometimes discovered by chance, without any prior symptoms being known. More often, however, patients visit their doctor with complaints of pain, fatigue, nausea or weight loss. A preliminary examination reveals that these complaints are caused by a yet unknown tumor. If this tumor cannot be identified, even after an extensive examination, this is known as CUP.\u00a0<\/p>\n<\/div>\n\n\n\n

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Long diagnostic process\u00a0<\/h2>\n\n\n\n

A diagnosis of cancer is bad news in itself, but if you have CUP then you have an additional worry. If the cause is unknown, a targeted treatment cannot be provided. As a patient, you are often referred from one specialist to another, while throughout that process the metastases continue to grow.\u00a0<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Accurate imaging\u00a0<\/h2>\n\n\n\n

There is no time to lose with these patients. The right diagnosis needs to be made as soon as possible, and this requires two steps: the first step is to create an accurate image using a high-quality CT scan or PET-CT scan. The second step is an extensive tissue analysis.\u00a0<\/p>\n<\/div>\n\n\n\n

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Tissue analysis\u00a0<\/h2>\n\n\n\n

A tissue analysis requires a biopsy of the metastasis. If this does not produce a clear diagnosis, we can perform a complete DNA test on that tissue. Whole Genome Sequencing<\/a> (WGS) usually enables us to identify the primary tumor. <\/p>\n\n\n\n

But there is another important advantage of WGS: sometimes we identify mutations (changes to the hereditary material of the tumor) for which a targeted treatment is available. <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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