{"id":8476,"date":"2025-02-02T21:26:45","date_gmt":"2025-02-02T20:26:45","guid":{"rendered":"https:\/\/www.hartwigmedicalfoundation.nl\/?page_id=8476"},"modified":"2025-02-11T11:05:30","modified_gmt":"2025-02-11T10:05:30","slug":"actin","status":"publish","type":"page","link":"https:\/\/www.hartwigmedicalfoundation.nl\/en\/actin\/","title":{"rendered":"ACTIN"},"content":{"rendered":"\n
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For patients with metastatic cancer, multiple systemic treatment options may be available at a certain moment in time. In treatment decision making, the oncologist and patient discuss the treatment options including a prediction of expected treatment benefit for the specific patient, and weigh the benefit against potential negative side-effects. <\/p>\n\n\n\n

Within ACTIN (Algorithmic Cancer Treatment Initiative), the aim is to develop a system to support oncologists and patients in treatment decision making. The system is developed as a suite of algorithms that identify all possible treatment options (standard-of-care and experimental) for the specific patient and predict the personal expected benefit of treatments (in terms of survival) based on published literature and real world treatment efficacy evidence.  <\/p>\n\n\n\n

ACTIN is developed in close cooperation with hospitals, to tailor the output of the algorithms to meet clinical needs and ensure tight integration into the hospital infrastructure to promote seamless usage by physicians.  <\/p>\n<\/div>\n<\/div>\n\n\n\n

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What was the reason this project was started? <\/h2>\n\n\n\n

Results displayed within Hartwig\u2019s whole genome sequencing diagnostic product (OncoAct) can be indicative of experimental or standard-of-care treatments. However, other clinical factors are relevant for treatment decision making as well, such as radiology results, pathology results and lab results. In addition, interpretation of molecular results can be challenging, both from a biological or analytical point of view and considering new evidence and indications are evolving rapidly (for example as described in this article<\/a>). <\/p>\n\n\n\n

The ACTIN initiative started in summer 2021 as a collaboration between Erasmus MC and Hartwig Medical Foundation, with the aim to build a suite of algorithms to address these challenges.<\/p>\n<\/div>\n\n\n\n

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What are the key principles of the ACTIN system? <\/h2>\n\n\n\n

For the development of the ACTIN system, the following principles are adhered to: <\/p>\n\n\n\n