{"id":11971,"date":"2026-11-12T10:05:28","date_gmt":"2026-11-12T09:05:28","guid":{"rendered":"https:\/\/www.hartwigmedicalfoundation.nl\/?p=11971"},"modified":"2026-11-12T10:05:29","modified_gmt":"2026-11-12T09:05:29","slug":"health-rewired-accelerates-personalized-care-patients-with-cancer","status":"publish","type":"post","link":"https:\/\/www.hartwigmedicalfoundation.nl\/en\/health-rewired-accelerates-personalized-care-patients-with-cancer\/","title":{"rendered":"Health ReWireD accelerates personalized care for patients with cancer"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Health ReWireD demonstrates how we can better utilize data to provide tailored care to patients. For this to happen, the foundation must first be right. That starts with healthcare data being properly documented. Internist-oncologists Dr. Hilde Nienhuis (UMC Utrecht and Hartwig Medical Foundation) and Dr. Robert Jan Kwakman (UMC Utrecht and vice-chair of PLCRC) share how they are handling this.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Making better use of data for high-quality personalized care allows patients to receive the best possible treatment while enabling us to gain new insights for the future. That is a valuable goal, but how do you achieve it? Not by just talking about it, according to Hilde Nienhuis. \u201cOften it stops there. There are initiatives, but they frequently focus on using data for purposes other than direct patient care. In doing so, you skip the foundation: the source where the data originates.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>In brief<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Health ReWireD aims to provide personalized treatment advice to every cancer patient.<\/li>\n\n\n\n<li>The project focuses on patients with colorectal or lung cancer.<\/li>\n\n\n\n<li>It is a collaboration between the regional cancer care network Oncomid, Hartwig Medical Foundation, and IKNL.<\/li>\n\n\n\n<li>The objective is an effective way to collect and share data. This allows patient data to be used for patient treatment, care evaluation, and research.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Health ReWireD aims to offer personalized treatment advice to every patient by learning from every patient. The project originated in a unique way. Robert Jan Kwakman explains: \u201cThe initiators of PLCRC, the Prospective Dutch Colorectal Cancer cohort, wanted to conduct research with routine care data together with Hartwig Medical Foundation. However, they could not directly answer the research question properly because the data was not recorded adequately. Realizing this needed improvement was the catalyst for Health ReWireD.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The project initially focuses on colorectal and lung cancer. \u201cThese are common types of cancer,\u201d Nienhuis explains. \u201cSo there are many patients. This means we can make a difference quickly through better data utilization.\u201d For colorectal cancer, data is already being collected within PLCRC.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Which data are needed?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To extract essential data from electronic health record systems (EHRs) &#8211; the digital system in which hospitals and healthcare providers track all medical records of a patient &#8211; it must first be clear which data are needed and for what purpose. \u201cCurrently, we have to do this afresh for every research question, manually extracting variables for a specific group of patients from the EHR,\u201d says Nienhuis. \u201cAdded together, that is a tremendous amount of work. To keep the effort manageable and organize it effectively, we are starting within the Oncomid network.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">All hospitals participating in Oncomid have designated an oncologist. These oncologists work together to compile a list of the most critical data required. Such a list is called a minimum clinical dataset, established using the Delphi method.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hartwig Medical Foundation funds the project management. Nienhuis: \u201cThis aligns with its goals and vision: learning from every patient. Therefore, we want to use clinical care data to improve care for future patients. It is also important to have DNA research data alongside data on disease and treatment. That helps when we later want to conduct research and evaluate healthcare quality.\u201d<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u201cThis aligns with goals and vision from [Hartwig Medical Foundation]: learning from every patient. Therefore, we want to use clinical care data to improve care for future patients&#8221;. dr. Hilde Nienhuis<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">DNA changes can occur at different moments and in various ways during life. This can happen, for example, due to exposure to UV radiation from the sun or smoking, but errors can also occur spontaneously during cell division. These DNA alterations can play a role in the onset and development of cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IKNL is also participating in the project. \u201cThe project manager for Health ReWireD works for IKNL as well,\u201d says Nienhuis. \u201cIKNL has long collected data on patients and their treatment. We ultimately want to use those data to compare healthcare across different hospitals. IKNL has extensive experience in that area.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Properly recording data<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Automatically reusing data from the EHR for research to evaluate care is technically complex. Nienhuis: \u201cFirst, we need to know where all data are located within the EHR. That is why we started mapping data in two Oncomid hospitals. Some data can be mapped well and are already structured in the system, but that is not true for all data. In those cases, we must ensure that those data are also recorded in a standardized manner. Sometimes this can be done via search queries in the EHR, as currently done in IKNL&#8217;s <a href=\"https:\/\/iknl.nl\/projecten\/ronda\">RONDA project<\/a> (Realtime Oncology Data).\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">More is needed. Kwakman: \u201cWe also need to engage with EHR software vendors. Clinicians currently enter data in multiple places and repeatedly type information. We need to reduce this administrative burden. Consequently, adjustments to the EHR will be necessary in every hospital.\u201d<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">&#8220;We need to reduce this administrative burden&#8221;, dr. Robert Jan Kwakman<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">Nienhuis adds: \u201cThe European Health Data Space imposes requirements in this area. But we must also investigate within hospitals how we can improve data entry by structuring it on the backend of the system. We are exploring whether AI can help with this. While there are no fixed guidelines for this yet, we can test whether it works and is reliable.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Hospitals eager to join<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Considerable work is required for Health ReWireD. \u201cThe initial idea was to start on a small scale,\u201d says Kwakman. \u201cWe want to test if it works first. If successful, we hope to scale up quickly.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">He notes great enthusiasm in the field. A number of centers have already signed up to participate. Additionally, several hospitals outside Oncomid participated in the Delphi consensus round, where experts provide feedback over multiple rounds to reach agreement on the essential data required.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">During this process, they helped build the list of essential data. That list was partly designed to build support among oncologists, as they will be more willing to record data if the purpose is clear.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Dutch Society for Medical Oncology (NVMO) is also deliberating on this list. \u201cThis is also being discussed at the IZA Roundtables,\u201d says Nienhuis. These are Integrated Care Accord (IZA) consultations in which healthcare providers, hospitals, and patient representatives make agreements on organizing care better, including care quality and inter-hospital collaboration. \u201cThat is why we have already shared our list; we naturally want to prevent multiple competing lists from emerging.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>High-quality and secure data<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Automating data collection raises questions regarding data quality and security. \u201cWe must validate that the data is accurate,\u201d Nienhuis says. \u201cIn the RONDA project, research was conducted to verify whether diagnosis and treatment data could be reliably automated from electronic health records by checking if automated data matched the original records. We must follow that exact approach.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kwakman adds: \u201cWe need to compare the automatically extracted data from the EHR against data manually extracted by IKNL data managers\u2014the current standard\u2014as well as against the treating oncologist&#8217;s interpretation, which represents the gold standard for the patient.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to Nienhuis, this validation must be ongoing. \u201cYou have to continuously ensure accuracy. Furthermore, the core dataset needs to be dynamic so it can adapt to new developments.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For data security, we can draw on procedures established by IKNL and Hartwig Medical Foundation. Nienhuis: \u201cTools already exist to pseudonymize data before it leaves the EHR. Additionally, IT specialists from hospitals and IKNL can help secure systems, manage user authorizations, and ensure no more data is shared than necessary for the intended purpose.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Step by step<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Both acknowledge that Health ReWireD poses a significant challenge. \u201cHealthcare providers currently make limited use of data to improve care, and we want to change that,\u201d Nienhuis says. Kwakman concurs: \u201cSurgical specialties track and measure treatment outcomes much more effectively, whereas medical oncology lags behind. However, I believe higher data quality will help us learn from one another.\u201d<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u201cHealthcare providers currently make limited use of data to improve care, and we want to change that,\u201d dr. Hilde Nienhuis<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">Nienhuis shares this view: \u201cUnderstanding the exact patient population in question and having comparative benchmark data from other hospitals will foster confidence in what we are doing, encouraging active participation from hospitals.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nienhuis expects the project to evolve step by step. \u201cI don&#8217;t expect us to seamlessly extract all variables from EHRs right away,\u201d she says. \u201cTaking the first step in 2027 is our primary milestone on the horizon.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">And beyond that? Kwakman: \u201cThe goal is to have patient data available real-time, fully structured, and complete across Oncomid hospitals by 2030.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>This article is a abridged version of the original article published on October 6, 2026 on<\/em> <a href=\"https:\/\/precisieoncologie.nl\/nieuws\/health-rewired-versnelt-de-weg-naar-gepersonaliseerde-kankerzorg\/\"><em>PrecisieOncologie.nl<\/em><\/a><em>, written by Frank van Wijck, MSc, science journalist.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Health ReWireD demonstrates how we can better utilize data to provide tailored care to patients. For this to happen, the &hellip;<\/p>\n","protected":false},"author":15,"featured_media":11964,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[93,85,76,73],"tags":[],"class_list":["post-11971","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hartwig-medical-foundation","category-learning-healthcare-system","category-molecular-diagnostics","category-personalized-treatment"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Health ReWireD: Advancing Personalized Cancer Care<\/title>\n<meta name=\"description\" content=\"Discover how Health ReWireD uses healthcare data to improve personalized cancer care and advance oncology research.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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