Vignettes

Insights into tumor landscapes

To provide more insights into the data contained in the Hartwig database and the differences between tumor types, we have created so-called vignettes. These (automated) figures offer a graphical overview of the molecular characteristics of various tumors. At the bottom of the page, you will find the complete list where the collection can be viewed and dowloaded.

For example, you can examine the processes that play an important role in the occurrence of DNA errors in different tumor types.

Here are a few examples of processes that cause mutations in three different tumor types. On the left: skin, where UV damage is the primary source of mutations. In the middle: lung, where smoking causes the most harm. On the right: bladder, where damage from APOBEC enzymes (normally an anti viral response that can be deregulated in tumors) is a main contributor.

Genomic landscapes per tissue/tumor type

The vignettes are automatically generated from the Hartwig database, a detailed explanation of what information is included and what the figures mean is described in the appendix. At the bottom of the page you can also find a file with all vignettes in an overview.

Some types of cancer cannot be linked to a specific organ or subtype, such as primary tumor unknown or cancer in young people, these have been analysed separately to support research into these often rarer types. For other tumor types, such as breast cancer, we can recognise (and separately analyse) specific subtypes through research. If you are interested in a specific cancer type or customised vignette please reach out.

Specific tumor type examples

Carcinoma of Unknown Primary (PTO/CUP)

Cancer in young adults (AYA)

Sarcomas (bone & soft tissue)

Liposarcoma

Cancer (sub) types – v2 April 2025

Adrenal Gland Neoplasms
Anogenital Carcinoma
Skin Melanoma
Skin Carcinoma
Neuroendocrine Tumors
Breast Carcinoma
Brain/CNS Cancer
Cancer of unknown primary (CUP)
Lower GI Carcinoma
Upper GI Carcinoma
Gynecological Carcinoma
Head and neck Carcinoma
Kidney Carcinoma
Liver Cancer
Lung Cancer
Pancreaticobiliary System Cancer
Mesothelioma
Prostate Carcinoma
Soft tissue and Bone Neoplasms
Thymus Neoplasms
Thyroid Gland Carcinoma
Urothelial Tract Carcinoma

The vignettes are automatically generated from the Hartwig database. A detailed explanation of the included information, cut-offs and the meaning of the figures can be found in the documentation.