Actionable metastatic cancer genome is remarkably stable over time, despite treatment with drugs
A one-time analysis of the entire tumor DNA is almost always sufficient to find all DNA errors that may be relevant for treating metastatic cancer. This is because actionable DNA errors remain remarkably stable over time, despite treatment with drugs. This discovery was made by Dutch researchers in a study led by the Netherlands Cancer Institute. The researchers used data from the Hartwig Medical Database for their research. They published their findings on August 9 online in the scientific journal Nature Medicine.
More information
- Publication in Nature: Joris van de Haar et al, ‘Limited evolution of the actionable metastatic cancer genome under therapeutic pressure’
- Paper in The Journal of Molecular Diagnostics: Clinical validation of Whole Genome Sequencing for cancer diagnostics
- Video voor treating physicians and pathologists about one-time analysis of the entire tumor DNA
- More information about WGS and the extensive DNA test for Cancer Diagnostics: OncoAct.nl
All news
Also read
Whole Genome Sequencing on Cerebrospinal Fluid: No Biopsy, Yet a Report
Whole genome sequencing is typically only performed on tissue biopsies. In collaboration with Hartwig Medical Foundation, a clinical molecular biologist …
Single WGS analysis of metastases is sufficient in most cases
DNA analysis of the tumor is of crucial importance to determine treatment options for patients with metastasized lung cancer. But …
The starting point – always the patient
Frank van Wijck, science journalist Ele Visser is handing over his position as chairman of Hartwig Medical Foundation’s Data Access Board …
In our profession, we need to know everything about the patient, but we also want to know as much as possible about the patient’s tumor.