Actionable metastatic cancer genome is remarkably stable over time, despite treatment with drugs
A one-time analysis of the entire tumor DNA is almost always sufficient to find all DNA errors that may be relevant for treating metastatic cancer. This is because actionable DNA errors remain remarkably stable over time, despite treatment with drugs. This discovery was made by Dutch researchers in a study led by the Netherlands Cancer Institute. The researchers used data from the Hartwig Medical Database for their research. They published their findings on August 9 online in the scientific journal Nature Medicine.
More information
- Publication in Nature: Joris van de Haar et al, ‘Limited evolution of the actionable metastatic cancer genome under therapeutic pressure’
- Paper in The Journal of Molecular Diagnostics: Clinical validation of Whole Genome Sequencing for cancer diagnostics
- Video voor treating physicians and pathologists about one-time analysis of the entire tumor DNA
- More information about WGS and the extensive DNA test for Cancer Diagnostics: OncoAct.nl
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Cancers will increasingly meet the definition of ‘rare’ in terms of the molecular profiles that make each tumor unique. The more research we can do into this, the better we will be able to offer patients personalized treatment in the future. Whole Genome Sequencing and studies like DRUP are making an important contribution to this.