Actionable metastatic cancer genome is remarkably stable over time, despite treatment with drugs
A one-time analysis of the entire tumor DNA is almost always sufficient to find all DNA errors that may be relevant for treating metastatic cancer. This is because actionable DNA errors remain remarkably stable over time, despite treatment with drugs. This discovery was made by Dutch researchers in a study led by the Netherlands Cancer Institute. The researchers used data from the Hartwig Medical Database for their research. They published their findings on August 9 online in the scientific journal Nature Medicine.
More information
- Publication in Nature: Joris van de Haar et al, ‘Limited evolution of the actionable metastatic cancer genome under therapeutic pressure’
- Read the complete article on the Antoni van Leeuwenhoek website
- Paper in The Journal of Molecular Diagnostics: Clinical validation of Whole Genome Sequencing for cancer diagnostics
- Video voor treating physicians and pathologists about one-time analysis of the entire tumor DNA
- More information about WGS and the extensive DNA test for Cancer Diagnostics: OncoAct.nl
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We want to extract the maximum amount of information from the patient’s tumor. This DNA test is the The complete DNA test is the best available tool to extract the maximum amount of information from the patient’s tumor. We only need one tissue sample with sufficient tumor cells. We literally analyze the entire genome, including parts of the DNA that show mutations of which we don’t yet know the importance. This test is tumor-independent and future-proof. These are the two most important advantages of WGS.