DR-318 The causes and consequences of structural variations in cancer
Structural variations (SVs) are large scale changes of DNA, which include deletions, duplications, inversion, translocations and other more complex forms. We aim to study the causes of somatic SVs in cancer and elucidate how they contribute to tumor initiation, progression and metastasis. We will develop novel methods to analyze the genomic and transcriptomic sequencing data. We expect to discover new genetic factors and genes contribute to the disease and improve disease prevention and treatment.
Lixing Yang, University of Chicago, USA
Back to newsMore news
Unique insights in the differences between primary and metastatic cancer by large-scale DNA data analyses
Researchers have obtained valuable insights into the development of tumors from a unique Dutch data collection. These insights provide relevant …
Automatically the right trial and treatment with ACTIN: A new step in cancer care
Imagine you have a patient with cancer sitting across from you: can’t be cured, but he is determined to try …
Unraveling of genetic mechanism behind tumor formation may improve targeted treatment for cancer patients
Genetic alterations in the FGFR2 gene occur in various cancer types and represent a promising target for therapies. However, clinical …
WGS is a helpful addition to our toolbox, alongside the classic HE, IHC and the (broad) NGS panels and should ideally be available in every regional oncology network