DR-435 The role of SMC5/6 in colorectal cancer genome stability
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DR-435 The role of SMC5/6 in colorectal cancer genome stability
Colorectal cancers have high levels of mutations and genome instability. While this enables tumors to become metastatic, it also may …
DR-433 Comparative flux balance analysis of metabolic networks in metastases across multiple cancer types
Tumours often exhibit different metabolic features than non-cancerous tissue. However, studying metabolism in patients has technical limitations that hold back …
DR-430 New transcriptional subgroups of colorectal cancer patients harbouring the BRAF V600E mutation
Colorectal cancer (CRC) remains the second most common cause of cancer death in the world. Approximately 12 % of CRC patients have a mutation in the …
DR-427 The role of whole genome doubling in cancer evolution and diagnostics
Whole genome doubling (WGD) is one of the most frequent aberrations that disrupt the genome of cancers. WGD is associated …
DR-424 Dissecting cancer cell-intrinsic mechanisms dictating the immune landscape of cancer
Immunotherapy has shown great success in treating multiple cancer types. However, not all patients benefit from immunotherapy. We are studying why …
DR-422 Investigating the mechanisms of epithelial/mesenchymal plasticity and metastasis
Metastasis to distant organs is the major cause of cancer-related deaths. The recent advancements in DNA sequencing technology, have significantly …
DR-432 Exploring molecular mechanisms involved in lung cancer progression and prediction of clinical outcomes
This project aims to improve lung cancer treatment by studying the complete genetic makeup of cancer cells. We will use …
DR-404 PRIME-ROSE
The PRIME-ROSE project (Precision Cancer Medicine Repurposing System Using Pragmatic Clinical Trials) is a European initiative to make targeted therapies—originally …
DR-361 A systematic analysis for the cancer fitness landscape between primary and metastatic tumors
We aim to demonstrate that the optimal activity-fitness level (cancer fitness) of cancer genes can vary depending on the tumor …
DR-425 Investigation of mutational processes and selection in cancer metastases
Cancer is a genetic disease driven by mutations in certain parts of the genome. We aim to study the distribution …
DR-429 Structural Variation Signatures and ABC transporters in Ovarian Cancer
This project explores the genomic heterogeneity of high-grade serous ovarian carcinoma (HGSC) by developing a method to identify structural variation …
DR-421 Molecular functions of steroid hormones in promoting prostate cancer progression
Prostate cancer relies on steroid hormones for development and progression. Hence, targeting steroid hormone pathways by androgen deprivation therapy (ADT) …
We zijn trots dat we samen met Hartwig Medical Foundation de uitgebreide DNA-test gereed hebben gemaakt voor gebruik in de standaarddiagnostiek. Bovendien levert de DNA-test belangrijke informatie op voor een lerend zorgsysteem waarin we toekomstige patiënten nog beter kunnen behandelen.