DR-503 Characterizing ABCB1 fusions in drug-resistant cancers
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DR-503 Characterizing ABCB1 fusions in drug-resistant cancers
ABCB1 encodes a protein that causes chemotherapy resistance. We aim to determine what causes ABCB1 expression in drug-resistant cancers. This …
DR-494 Analysis of MYC-driven transcriptional programs and genomic mutations linked to immune checkpoint inhibitor resistance in melanoma and non-small cell lung cancer.
Through comprehensive bioinformatic analysis of datasets, the purpose of our project is to identify MYC-dependent signatures and to assess their …
DR-478 Understanding the Abscopal effect in Prostate cancer – Primary and Metastatic Tumour Crosstalk
The project aims to identify immune cell infiltration within metastatic prostate cancer samples and evaluate if radiation therapy modifies these …
DR-492 Whole genome sequencing of small intestinal adenocarcinomas
Small intestinal adenocarcinoma (SIA) is a rare cancer with poor survival outcomes and limited treatment options. Knowledge of its biology …
DR-454 The genomic landscapes of MLH1-mutated and/or CTNNB1-mutated colorectal carcinomas
Colorectal cancer (CRC) is a heterogeneous disease comprising subtypes with distinct clinical and/or molecular characteristics. Roughly, two major categories of …
DR-465 Investigating the role of tandem repeat expansions in cancer risk
This project seeks to use genome sequencing data from tumor samples to look for a specific type of genetic mutation …
DR-456 Developing a Foundation Model for Cancer Genomes
Mutations in the DNA of cells are the base for cancer formation. We plan to develop an artificial intelligence tool …
DR-453 Mapping neotelomeres and chromosomal arm fusions in primary and metastatic cancers
Cancer cells often face DNA damage, which must be repaired to ensure their survival. In previous research, we discovered that …
DR-461 Identifying biomarkers that predict outcomes in BRAFV600E mutant colorectal cancer
This project aims to understand how genetic alteration in an important cancer signalling pathway can impact treatment response and prognosis …
DR-469 Large scale characterization of the Pancreatic Ductal Adenocarcinoma microenvironment and its relation to prognosis and treatment benefit
We aim to characterize the tumor microenvironment (TME) of Pancreatic Ductal Adenocarcinoma (PDAC) using four big primary cohorts with bulk …
DR-471 Whole Genome CRISPR Screening Identifies Novel Regulators of Mismatch Repair in Lynch-like Syndrome
This project aims to uncover novel genetic regulators of mismatch repair (MMR) that may explain the molecular basis of Lynch-like …
DR-472 Identification of CN-LOH in CRC
Patients with colorectal cancer (CRC) often have major alterations in the genomic information. These mutations are traditionally assessed to occur …
Kankers zullen steeds vaker voldoen aan de definitie van ‘zeldzaam’ als het gaat om de moleculaire profielen die elke tumor uniek maakt. Hoe meer onderzoek we hiernaar doen, hoe beter we in de toekomst elke patiënt een op maat gemaakte behandeling kunnen aanbieden. Whole genome sequencing en studies als DRUP leveren hier een belangrijke bijdrage aan.