DR-535 An integrative framework to infer candidate synthetic lethal genetic interactions in Dutch cancer genomes
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DR-535 An integrative framework to infer candidate synthetic lethal genetic interactions in Dutch cancer genomes
The objective of this study is to infer candidate genetic interactions (combinations of two mutated genes with advantageous or synthetic …
DR-518 Impact of driver gene expression states on FOLFIRINOX response in pancreatic ductal adenocarcinoma
Pancreatic cancer has a very poor survival rate, and many patients receive chemotherapy that does not help them and causes …
DR-528 Computational modelling of tumour evolution and treatment resistance in prostate cancer towards personalised therapeutic strategies
This project will use computational modelling to simulate how advanced prostate cancer (PC) evolves, including the impact of different combinations …
DR-536 Deciphering selection patterns in somatic copy-number events
Changes in DNA copy-number are a key feature of cancer and play an important role in tumor development and progression. …
DR-516 Genetic, epigenetic and transcriptomic determinants of heterogeneity-driven variation in radiation response in oesophageal adenocarcinoma
Oesophagogastric adenocarcinoma (OGA) is associated with substantial heterogeneity. Less than 1 in 5 patients respond adequately to external beam radiotherapy …
DR-517 Whole-Genome and Transcriptome Sequencing in Primary CNS Tumours: A Comparative Analysis of Hartwig and Canadian Cohorts
This project will study genomic data from patients with primary central nervous system (CNS) tumours, including whole-genome and transcriptome sequencing …
DR-523 Precise and Cost-Effective Identification of Homologous Recombination Deficiency
Patients whose cancer cells have defective DNA repair, known as the homologous recombination deficiency (HRD) phenotype, benefit from treatment with …
DR-522 Understand mechanism of resistance in HR deficient cancers
Patients with homologous recombination deficiency (HRD), a condition when cancer cells cannot effectively repair DNA double-strand breaks. HRD tumours, especially …
DR-485 Mapping MSK-IMPACT genetic insights to large scale genomic and transcriptomic events in breast cancer
Molecular alterations occurring at the genomic level represent the mainstay process promoting breast cancer development. In this context, at Memorial …
DR-511 The biological and clinical consequences of structural variants across tumor types
Cancers are characterized by substantial genomic instability, including large genomic alterations known as structural variants (SVs), which remain relatively underexplored. …
DR-514 Sex-Specific Genomic Differences in Early-Onset and Average-Onset Esophagogastric Adenocarcinoma: An Integrated Whole-Genome Study
This project studies whether younger patients with esophageal or gastric adenocarcinoma have different genetic tumour characteristics than older patients, and …
DR-498 Interoperable Multi-Modal Data Platform for AI-Driven Precision Medicine Biomarker Discovery at the Future Medicines Institute
Biomedical data are often poorly standardised and fragmented across formats, limiting integration and slowing the discovery of biomarkers that can …
We zijn trots dat we samen met Hartwig Medical Foundation de uitgebreide DNA-test gereed hebben gemaakt voor gebruik in de standaarddiagnostiek. Bovendien levert de DNA-test belangrijke informatie op voor een lerend zorgsysteem waarin we toekomstige patiënten nog beter kunnen behandelen.