DR-249 Organotropism: gaining new insights into the molecular landscape of prostate cancer metastases
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DR-249 Organotropism: gaining new insights into the molecular landscape of prostate cancer metastases
While localized prostate cancer can be cured, metastastatic disease is associated with high morbidity and mortality. Prostate cancer typically metastasizes …
DR-248 Essential regulatory elements on high-level amplicons
Only 2% of the human genome contains protein-coding genes. Their expression depends on the regulatory elements in the surrounding “non-coding” …
DR-247 A comprehensive analysis of mutational processes and signatures in primary and metastatic cancer tumors
Tumor metastasis involves dissemination of cancer cells of primary tumors to distant organ sites. Though current cancer research has delineated …
DR-246 Investigating cumulative effect and mutational processes underlying coding and non-coding mutations in metastatic cancer
This study aims to quantify the aggregated effect of mutations in metastatic tumors and compare it with those in primary …
DR-243 Development and standardization of benchmarking strategies for identification of genomic variants in cancer
As part of the EUCANCan project, a federated network for harmonized genomic and phenotypic data sharing, we aim to foster …
DR-242 Measuring the evolutionary dynamics of positive and negative selection in metastatic cancers
In this project we aim at combining mathematical modelling of tumour evolution with cancer genomic data to measure fundamental evolutionary …
DR-241 OPTN expression in Triple negative breast cancer
Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat due to its aggressive characteristics and low …
DR-239 The causes and consequences of structural variations in cancer
Structural variations (SVs) are large scale changes of DNA, which include deletions, duplications, inversion, translocations and other more complex forms. …
DR-237 A computational framework for precision medicine of hereditary melanoma cancer
The overall objective of our study is to assess if melanoma with a specific DNA mutation (in the CDKN2A gene) …
DR-235 Exploring focal amplifications across cancers
Cells may grow more quickly when a specific subset of genes called oncogenes are activated. Normally, two DNA copies. each …
DR-231 Genome specificity of Mutagenesis
HER2-positive breast cancer is an aggressive subtype driven by amplification of the Her2/Erbb2 gene. This oncogene is amplified and implicated …
DR-230 The impact of genomic alterations in breast cancer pathogenesis
HER2-positive breast cancer is an aggressive subtype driven by amplification of the Her2/Erbb2 gene. This oncogene is amplified and implicated …
Een complete genetische analyse zou onderdeel moeten zijn van de standaarddiagnostiek bij iedere patiënt met kanker. Dat draagt bij aan een beter, afgestemd behandeladvies. Zo verminderen we over- en onderbehandeling, maken we tegelijkertijd de zorg kosten-effectiever en houden we hem betaalbaar.