DR-225 Comprehensive molecular characterization of mitochondrial genomes in human metastatic cancers
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DR-225 Comprehensive molecular characterization of mitochondrial genomes in human metastatic cancers
Cancer is a deadly disease affecting millions of people worldwide. Tumor metastasis is the most frequent cause of death. The …
DR-222 Microbiome in metastatic cancer
In this study we will investigate the microbiome in metastatic cancer. We will use whole genome sequencing data from solid …
DR-221 Multi-omics profiling of tumors
Cancer is caused by mutations in the DNA, which can be analyzed by sequencing the tumor’s DNA. We can observe …
DR-220 An exploratory study on genomic correlates of anti-tumour immunity in castration-resistant prostate cancer.
Checkpoint inhibitors have failed to demonstrate a survival benefit in unselected castration-resistant prostate cancer (CRPC) patients. Nevertheless, biochemical and radiographic …
DR-219 Colorectal cancer (CRC) predisposition
We will use whole genome sequencing data derived from blood or normal tissue of colorectal cancer (CRC) patients in a …
DR-216 Uncovering the landscape of MHC peptides derived from low translation fidelity and their their impact on anti-cancer immunity
The purpose of the project is to search for repeating mutations in genes related to translation in cancer. Such genes …
DR-213 Copy number changes, DNA repair mechanisms and cisplatin resistance in germ cell tumors
We observed specific chromosomal copy number changes in germ cell tumors that are proven to be resistant to cisplatin-based chemotherapy. …
DR-249 Organotropism: gaining new insights into the molecular landscape of prostate cancer metastases
While localized prostate cancer can be cured, metastastatic disease is associated with high morbidity and mortality. Prostate cancer typically metastasizes …
DR-248 Essential regulatory elements on high-level amplicons
Only 2% of the human genome contains protein-coding genes. Their expression depends on the regulatory elements in the surrounding “non-coding” …
DR-247 A comprehensive analysis of mutational processes and signatures in primary and metastatic cancer tumors
Tumor metastasis involves dissemination of cancer cells of primary tumors to distant organ sites. Though current cancer research has delineated …
DR-246 Investigating cumulative effect and mutational processes underlying coding and non-coding mutations in metastatic cancer
This study aims to quantify the aggregated effect of mutations in metastatic tumors and compare it with those in primary …
DR-243 Development and standardization of benchmarking strategies for identification of genomic variants in cancer
As part of the EUCANCan project, a federated network for harmonized genomic and phenotypic data sharing, we aim to foster …
In ons vak is het heel belangrijk om naast de kennis over de patiënt meer kennis te hebben van de tumor van de patiënt.