DR-225 Comprehensive molecular characterization of mitochondrial genomes in human metastatic cancers

Cancer is a deadly disease affecting millions of people worldwide. Tumor metastasis is the most frequent cause of death. The accumulation of mutations in the DNA explain the onset and progression of this disease. The main attention to understand metastasis has been focused on mutations in the cell nuclear DNA. However, the mitochondrial genome may play an important role in the development and progression of metastasis. The WGS data provided by the Hartwig Medical Foundation will help us to unravel a comprehensive map of mtDNA alterations in tumor metastasis and explore its role in cancer prognosis and treatment response.

Cristina Rodriguez-Antona, Spanish National Cancer Research Center (CNIO), Spain