DR-158 Measuring the evolutionary dynamics of positive and negative selection in metastatic cancers
- Algoritmes
- Behandeling op maat
- Betaaltitel
- Biomarker
- cfDNA
- DNA
- Educatie
- Geen onderdeel van een categorie
- GENAYA project
- Hartwig Medical Database
- Hartwig Medical Foundation
- Hergebruik data
- Innovatie
- IT
- Kwaliteit
- Lab proces
- Lerend zorgsysteem
- Medicijn
- Moleculaire diagnostiek
- OncoAct
- oncoanalyser
- OncoAnalyser Dx
- Onderzoek
- Participerende ziekenhuizen
- Pipeline
- Preventie
- Primaire Tumor Onbekend
- Uitbehandeld
- Verhalen patiënten
- Werken in de cloud
- Wetenschappelijke publicaties
- Whole genome sequencing
- Zeldzame kankers
DR-158 Measuring the evolutionary dynamics of positive and negative selection in metastatic cancers
In this project we aim at combining mathematical modelling of tumour evolution with cancer genomic data to measure fundamental evolutionary …
DR-212 Molecular mechanisms of interplay between DNA repair pathways in pancreatic cancer chemo-resistance
Currently, only 20% of pancreatic cancer (PC) patients are qualified for surgery, constituting the only potentially curative treatment available. Despite …
DR-211 Drug response classifier for lung cancer patients
Lung cancer (LC) is the leading cause of cancer mortality. Despite a well-known therapeutic targets and thus a wide spectrum …
DR-210 Genetic causes of resistance to enzalutamide and abiraterone in metastasized castration-resistant prostate cancer patients
Androgen receptor inhibitors (ARi) are frequently used to treat metastatic prostate carcinomas. In this project, we focus on identifying genetic …
DR-209 Studying the association between replication timing and cancer mutational signatures
Mutations are changes in the DNA sequence which can cause cancer. We found that in melanoma and liver cancer different …
DR-208 “Characterisation and in-depth analysis of the genome and clinical correlates of metastatic prostate cancer patients for improved patient stratification. DR-208 is an extension of DR-071”
In this project we aim to use whole genome sequencing data to improve the way we treat patients with prostate …
DR-207 Validation of the WGS analysis pipeline
We have created a local copy of the netflow version of th eHMF WGS pipeline and aim to validate the …
DR-205 Identification of somatic variants of unknown significance affecting clinically actionable kinases
Many genomic alterations affecting known driver genes are still classified as variants of unknown significance (VUS). Especially VUS other than …
DR-202 Evolution of resistance to endocrine therapies in breast cancer
Endocrine therapies remain a core component of systemic therapy for patients with estrogen receptor positive breast cancer, but all patients …
DR-194 Microbiome in metastatic cancer
In this study we will investigate the microbiome in metastatic cancer. We will use whole genome sequencing data from solid …
DR-192 A comprehensive analysis of germline / somatic interactions
Over the last decade we have made significant progress in understanding which mutations are acquired by healthy cells before becoming …
DR-190 Development and standardization of benchmarking strategies for identification of genomic variants in cancer
As part of the EUCANCan project, a federated network for harmonized genomic and phenotypic data sharing, we aim to foster …
In ons vak is het heel belangrijk om naast de kennis over de patiënt meer kennis te hebben van de tumor van de patiënt.