DR-212 Molecular mechanisms of interplay between DNA repair pathways in pancreatic cancer chemo-resistance

Currently, only 20% of pancreatic cancer (PC) patients are qualified for surgery, constituting the only potentially curative treatment available. Despite promising clinical results for targeted therapies, the molecular subtypes of PC is not yet useful to guide clinical decision-making. Therefore, the main purpose of this project is to reveal genomic features, underlying the anti-cancer treatment response. We will perform whole-genome sequencing (WGS) analyses on PC patient’s genomes obtained from HMF and identify the genomic differences between sensitive and resistant tumors. This data mining will improve PC patient stratification toward targeted therapies, contributing to the development of personalized medicine.

Pawel Zawadzki Adam Mickiewicz University in Poznań Poland