DR-209 Studying the association between replication timing and cancer mutational signatures

Mutations are changes in the DNA sequence which can cause cancer. We found that in melanoma and liver cancer different portions of the genome have different mutation patterns. By combining this information with information about the order in which DNA is copied, we could identify subtypes of liver cancer with different survival rates. Expanding our approach to the Hartwig Medical foundation whole genome sequenced metastatic tumors, will allow the definition of tumor subtypes, which may display different clinical behavior in terms of survival, and response to various treatments, helping us to personalize cancer treatment.

Itamar Simon Hebrew University Israel