DR-211 Drug response classifier for lung cancer patients

Lung cancer (LC) is the leading cause of cancer mortality. Despite a well-known therapeutic targets and thus a wide spectrum of targeted therapies, the mechanisms associated with drug resistance are limited to identification of a point mutations in a particular genes. Therefore, the main purpose of the research project is to reveal all genomic features that differentiate responders and non-responders to a given treatment type. We will perform whole-genome sequencing data analyses on LC patients genomes from Hartwig Medical Foundation and develop a clinical predictor that will improve patient stratification toward anti-cancer therapies and provide long-term benefit from treatment.

Pawel Zawadzki Adam Mickiewicz University in Poznań Poland