DR-202 Evolution of resistance to endocrine therapies in breast cancer

Endocrine therapies remain a core component of systemic therapy for patients with estrogen receptor positive breast cancer, but all patients with advanced disease will eventually relapse. For many of them little is known of the details regarding how or why this happens. We are working on samples taken in a number of different clinical trials from patients who have have breast cancer that has become resistant to endocrine therapy. By comparing the findings from these studies with patients in the Hartwig dataset we hope to understand more about the mechanisms through which resistance develops.

Nick Turner The Institute of Cancer Research United Kingdom