DR-190 Development and standardization of benchmarking strategies for identification of genomic variants in cancer

As part of the EUCANCan project, a federated network for harmonized genomic and phenotypic data sharing, we aim to foster cancer research and its application to precision medicine in a clinical environment which requires an accessible, accurate, and standardized methodology to evaluate the procedures involved in the identification of tumour variants in cancer patients. The lack of easy-to-access and exhaustive benchmarking datasets and procedures together with the intrinsic difficulty of the variant identification process make the implementation of a personalized medicine program in oncology practically impossible for centers without access to bioinformatic expertise and computational power. This project aims to utilize validated tumor patients data from the Hartwig Medical Foundation cohort and other cancer initiatives to provide a complete benchmarking system to homogenize and make variant identification methodologies compatible.

David Torrents Barcelona Supercomputing Center Spain