DR-258 Impact of somatic mutations and prostate cancer risk SNPs on enhancer activity, interpatient heterogeneity and responsive gene expression in metastatic prostate cancer
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DR-258 Impact of somatic mutations and prostate cancer risk SNPs on enhancer activity, interpatient heterogeneity and responsive gene expression in metastatic prostate cancer
We have previously mapped in metastatic prostate cancer how genes are being regulated. Now, we aim to combine these results …
DR-257 Somatic mutations and germline variants at Estrogen Receptor / DNA binding sites and their impact on gene expression programs in metastatic breast cancer
Estrogen Receptor is a hormone-responsive protein, responsible for breast tumor growth. We found that DNA-binding specificity can predict treatment response, and …
DR-256 Altered genomic landscape of ER alpha in endometrium tumor
Endometrium cancer is one of the most common gynecological cancer and accounts for ~6% of all cancers in women. The …
DR-255 Mutational imprints of endogenous DNA damage
DNA carries the instructions to life but is also constantly damaged, causing mutation and disease. Sunlight and cigarette smoke are …
DR-254 PEGASUS: pancreatic and esophagogastric cancer: improving survival and quality of life through personalized medicine
Pancreatic cancer and esophagogastric cancer are among the most deadly forms of cancer: despite intensive treatment with chemotherapy and / …
DR-253 Comprehensive analysis of mutational signatures in metastatic cancers
The DNA in human cells are continuously exposed to internal and external challenges. The purpose of this project is to …
DR-252 Prostate cancer genomic evolution and signatures of DNA damage repair deficiencies
The purpose of our project is to identify genomic signatures related to DNA damage repair (DDR) defects in advanced prostate …
DR-251 Characterization of the oncogenic fusion landscape of microsatellite instability high solid tumors
Microsatellite instability (MSI) is a genomic phenomenon characterized by a high number of mutations in tumor DNA. This is due …
DR-250 Analysis of genomic structural alteration signatures in metastatic cancers
Genomic structural alterations are prevalent across many tumor types and can affect genes that drive cancer progression. It is important …
Zolang de behandelaar niet weet waar de primaire tumor zit, heeft hij ook geen gerichte behandelmogelijkheid en kan ook geen inschatting worden gegeven hoe lang iemand nog heeft.