DR-275 Identification of somatic mutations in non-coding regions including 5’UTR, 3’UTRs, and microRNAs

Thousands of cancer-driving mutations have been detected in the cancer genome. Some of them are used as cancer biomarkers or targets of cancer therapies. However, an overwhelming proportion of currently recognized cancer-driver mutations is located in protein-coding sequences, which encompass barely 2% of the genome. Therefore in this study, we are going to investigate cancer-associated mutations in the non-coding part of the genome. We will focus particularly on the characterization of gene-associated non-coding regions, i.e., 5’UTRs and 3’UTRs, and microRNA genes, to identify potential non-coding cancer drivers.

Piotr Kozłowski, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poland