DR-256 Altered genomic landscape of ER alpha in endometrium tumor

Endometrium cancer is one of the most common gynecological cancer and accounts for ~6% of all cancers in women. The vast majority of endometrium cancers are dependent on a hormone receptor, Estrogen receptor α (ERα). We aim to identify how changes in the DNA sequence of the tumor would affect the function of ERα, and how this would ultimately impact gene activity and tumor cell growth

Wilbert Zwart, Netherlands Cancer Institute, the Netherlands