DR-258 Impact of somatic mutations and prostate cancer risk SNPs on enhancer activity, interpatient heterogeneity and responsive gene expression in metastatic prostate cancer

We have previously mapped in metastatic prostate cancer how genes are being regulated. Now, we aim to combine these results with mutations and gene activation status in these and other tumor samples, to better understand how gene regulation and mutations are connected in metastatic prostate cancer.The aim is to better understand metastatic disease, and how this deviates from primary prostate cancer and between patients. This knowledge can ultimately guide us to design better treatment strategies and predict which patients are at risk of relapse.

Wilbert Zwart, Netherlands Cancer Institute, the Netherlands