DR-216 Uncovering the landscape of MHC peptides derived from low translation fidelity and their their impact on anti-cancer immunity

The purpose of the project is to search for repeating mutations in genes related to translation in cancer. Such genes lead to impaired translation of proteins. These proteins have a greater tendency to be degraded by the proteosome, and be presented on MHC of cancer cells, to the immune system. For example, T cells can respond and kill the cancer cell. Our aim is to associate these recurring mutations in sequencing data of patients, to patient response to treatment.

Yardena Samuels Weizmann Institute of Science Israel