DR-213 Copy number changes, DNA repair mechanisms and cisplatin resistance in germ cell tumors

We observed specific chromosomal copy number changes in germ cell tumors that are proven to be resistant to cisplatin-based chemotherapy. We will use the HMF data to verify that these changes indeed occur frequently in metastasized germ cell tumors and determine whether they also occur in other tumor types that are treated with platin-based chemotherapy. This will help verify the role of these chromosomal changes in general platin resistance and hopefully aid in identifying patients with initial or gained resistant tumors that might benefit from other treatment options.

Leendert Looijenga Prinses Maxima Centrum the Netherlands