DR-249 Organotropism: gaining new insights into the molecular landscape of prostate cancer metastases

While localized prostate cancer can be cured, metastastatic disease is associated with high morbidity and mortality. Prostate cancer typically metastasizes to lymph nodes and the bone, while metastases to organs like liver, lung or the peritoneum are less common. This project is aimed to describe what the differences are in the genomic (DNA) make up of prostate cancer metastases in the different sites. Knowledge hereof might spark further research into ‘site-preference’ and ‘site-specific alterations’ of the prostate cancer metastases genome, which ultimately might result in means to better treat or even prevent metastases.

Andre Bergman, Netherlands Cancer Institute, the Netherlands