DR-519 Deciphering the molecular landscape of sarcomas
- Algoritmes
- Behandeling op maat
- Betaaltitel
- Biomarker
- cfDNA
- DNA
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- GENAYA project
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DR-519 Deciphering the molecular landscape of sarcomas
Sarcomas are rare cancers that are difficult to diagnose and treat due to highly variable genetic profiles. This project uses …
DR-532 Investigating the relationship between extrachromosomal DNA and cancer outcomes
This project studies extrachromosomal DNA (ecDNA), circular DNA fragments that can carry extra copies of cancer-driving genes. We will analyze …
DR-491 Learning the cellular origins of rare cancer using single-cell chromatin landscape
Deciphering the cell of orgin (COO) of different cancers is critial for understanding tumor development and improving diagnostic and therapeutic …
DR-530 Uncovering the effects of genetic background on tumorigenesis through studying mutagenesis and selection
Cancer develops when DNA accumulates mutations over time, with inherited genetic factors influencing whether, when, and how aggressively it progresses. …
DR-539 Validation of RNA-seq derived mutational profiles using paired somatic and germline DNA references in multi-omics tumor profiling
This project evaluates the accuracy of computationally inferring genetic mutations directly from RNA-sequencing data. While RNA-seq is primarily used for …
DR-538 Single-cell analysis reveals possible biomarkers of dormant and awakened prostate cancer cells in bone: exploring clinical applications
When cancer spreads to bone, there is no effective treatment. Cancer cells can survive unnoticed for a long time in …
DR-535 An integrative framework to infer candidate synthetic lethal genetic interactions in Dutch cancer genomes
The objective of this study is to infer candidate genetic interactions (combinations of two mutated genes with advantageous or synthetic …
DR-518 Impact of driver gene expression states on FOLFIRINOX response in pancreatic ductal adenocarcinoma
Pancreatic cancer has a very poor survival rate, and many patients receive chemotherapy that does not help them and causes …
DR-528 Computational modelling of tumour evolution and treatment resistance in prostate cancer towards personalised therapeutic strategies
This project will use computational modelling to simulate how advanced prostate cancer (PC) evolves, including the impact of different combinations …
DR-536 Deciphering selection patterns in somatic copy-number events
Changes in DNA copy-number are a key feature of cancer and play an important role in tumor development and progression. …
DR-516 Genetic, epigenetic and transcriptomic determinants of heterogeneity-driven variation in radiation response in oesophageal adenocarcinoma
Oesophagogastric adenocarcinoma (OGA) is associated with substantial heterogeneity. Less than 1 in 5 patients respond adequately to external beam radiotherapy …
DR-517 Whole-Genome and Transcriptome Sequencing in Primary CNS Tumours: A Comparative Analysis of Hartwig and Canadian Cohorts
This project will study genomic data from patients with primary central nervous system (CNS) tumours, including whole-genome and transcriptome sequencing …
Zolang de behandelaar niet weet waar de primaire tumor zit, heeft hij ook geen gerichte behandelmogelijkheid en kan ook geen inschatting worden gegeven hoe lang iemand nog heeft.