DR-469 Large scale characterization of the Pancreatic Ductal Adenocarcinoma microenvironment and its relation to prognosis and treatment benefit

We aim to characterize the tumor microenvironment (TME) of Pancreatic Ductal Adenocarcinoma (PDAC) using four big primary cohorts with bulk mRNA (677 patients in total) and pre-estimated malignant cell fraction by either DNA copy number analysis or histology. This characterization will then be related to prognosis and treatment benefit, allowing for more personalized prognosis and treatment options. This characterization will also be applied to metastatic PDAC to study if the findings in primary PDAC hold true and to see which TME characteristics are often present in metastatic PDAC and thus might be related to PDACs metastatic potential.

Yongsoo Kim, Amsterdam UMC, the Netherlands