DR-287 Comparing metastatic and primary breast tumours through the lens of integrated subtypes

Under DR-129, we have generated preliminary data that shows differences in the distribution of our genomic breast cancer subtypes between primary tumours (non-HMF cohorts) and metastases (HMF cohort). We now wish to correlate these subtype assignments with patient’s clinical data, including treatment history and survival outcomes, to discover whether our genomic breast cancer subtypes could have predictive/prognostic utility in metastatic breast cancer, and to further characterise the genomic differences between primary and metastatic breast tumours.

Carlos Caldas, Cancer Research UK Cambridge Institute, United Kingdom