DR-175 “Comparing metastatic and primary breast tumours through the lens of integrated subtypes – RNA-seq. DR-175 is an extension of DR-129”

This request is an extenstion of DR-129 to include RNA data. The Personalised Breast Cancer Program (PBCP) is an initiative based at the Cancer Research UK Cambridge Institute and the Addenbrooke’s Hospital Breast Cancer Unit to sequence the DNA and RNA of breast cancer patients’ tumours. For every patient, their DNA was checked for mutations which could have an effect on which treatment would work best for them. Crucially, the results of the analysis are returned to the patient and their clinician within 12 weeks. However, most of the data in PBCP comes from primary breast tumours. We aim to understand how our findings from PBCP can be translated to metastatic tumours.

Carlos Caldas Cancer Research UK Cambridge Institute United Kingdom