DR-430 New transcriptional subgroups of colorectal cancer patients harbouring the BRAF V600E mutation

Colorectal cancer (CRC) remains the second most common cause of cancer death in the world.  Approximately 12 % of CRC patients have a mutation in the BRAF gene, which is associated with very aggressive disease. In recent years new drugs for this subpopulation of patients have been developed. Some survival improvements have been reported, however differences in response and duration between patients have been observed. The aim of this project is to better understand the underlying subgroups to improve patient stratification. For this purpose, current gene expression-based classification systems will be refined using the Hartwig Medical dataset and an artificial intelligence approach.

Jose Antonio Seoane Fernandez, Vall d’Hebron Institute of Oncology (VHIO), Spain