DR-146 Treatment with targeted therapy based on genetic profiling by whole genome sequencing in patients with solid tumours

In the past two decades, the exploration of molecular mechanisms and genetic information in cancer led to the new approaches for treatment. Despite its undesirable consequences, conventional chemotherapy is still the first-line treatment in metastastic cancer. Nowadays, targeted therapies (monoclonal antibodies and small molecules) are approved for some tumour types. Resistance to these agents is a challenging problem in the clinic and could be a result of activation of alternative molecular pathways involved in tumourigenesis. This finding highlights the need for further research to optimize treatment with targeted therapies by combining them in patients with more than one actionability.

Neeltje Steeghs Netherlands Cancer Institute the Netherlands