DR-101 Analysis of high resolution whole-genome sequencing (WGS) data to define structural rearrangements and copy number signatures-based associated with DNA repair deficiencies in metastatic castration resistant prostate cancer (mCRPC).

The purpose of our project is to derive genomic signatures based on presence of structural rearrangements and copy number from high resolution WGS data of advanced prostate cancer biopsies. The data we plan to use are the 212 high resolution WGS from the Lisanne F. van Dessel, et. al. study (The genomic landscape of metastatic castration-resistant prostate cancers using whole genome sequencing reveals multiple distinct genotypes with potential clinical). We aim to characterize the presence of specific signatures associated with the presence of mutations in DNA repair genes; with the final goal of using them as biomarker for predicting which patients could benefit from specific treatments.

Joaquin Mateo Vall d’Hebron Institute of Oncology Spain