DR-264 Genetic variation in the outcome of cancer

There were 18.1 million new cancer patients worldwide in 2020. Of these patients, some will recover after treatment while the others will develop deadly metastasis. There is accumulating evidence that cancer outcomes are determined by genetic factors. The Hartwig Medical Foundation dataset is a rich resource of clinical records and associated patient DNA sequence data, which offers a unique opportunity to identify genetic variants that influence cancer outcomes. By comparing the DNA sequences between cancer patients with good disease outcomes versus bad outcomes, we will identify genetic variants that influence cancer progression and metastasis, providing new targets for potential therapies.

Sohail Tavazoie, Rockefeller University, United States