DR-321 Analyzing the correlations between gene expressions and mutations in breast cancer

Combination of several markers is necessary to effectively detect and diagnose cancer. To look for such fingerprints high-throughput multi-omics data as well as sophisticated bioinformatics tools are required. The purpose of our project is to use the RNA-sequencing (RNA-Seq) and somatic mutations data of breast cancer patients along with their clinical data to re-establish the complete pipeline for the web portal muTarget (http://www.mutarget.com), previously developed by us. Our online platform will help search for new drug targets in a cohort of patients with a given mutation or identify patient cohorts with enriched expression when one has a drug target gene.

Balázs Győrffy, Research Centre for Natural Sciences, Hungary