DR-347 Comprehensive characterization of the immunogenomic landscape of metastatic tumors

Escape from immune surveillance is one of the hallmarks of tumorigenesis. In this study, we aim to perform an extensive characterization of tumor genomic events that may influence visibility and activity of surrounding immune cells, including the collection of neoantigens and the presence of genetic immune escape events, matched with the profiling of the tumor’s immune microenvironment. We expect that analyses will provide fundamental insights about the interplay between tumor evolution and the adaptive immune system, will aid in the identification of novel biomarkers of immunotherapy responses and will promote the development of in-silico frameworks for designing tailored immunotherapies.

Francisco Martínez-Jiménez, Vall d’Hebron Institute of Oncology (VHIO), Spain