DR-253 Comprehensive analysis of mutational signatures in metastatic cancers

The DNA in human cells are continuously exposed to internal and external challenges. The purpose of this project is to computationally derive specific footprints (signatures) in metastatic cancers that can give us clues regarding why they have become cancerous. We will use acquired and inherited mutation calls to explore and understand these characteristic patterns. The knowledge gained is of importance for personalisation of cancer management strategies.

Serena Nik-Zainal, University of Cambridge Clinical School, UK