DR-439 Optimization of the Diagnostic and Therapeutic Management of Cancers of Unknown Primary (CUP) Using AI: Integration of Transcriptomic Data to Predict Tumor Origin

Identifying the original tissue of a metastatic cancer is key to choosing the best treatment. Cancers of Unknown Primary (CUP) are cancers where the origin is unclear, making them hard to diagnose and treat. The AI tool TransCUPtomics uses genetic data (RNA-seq) to predict where the cancer started, helping doctors personalize treatments. Integrated into a French national expert group since 2020, it has identified the cancer’s origin in 64% of cases but needs improvement for the rest. This project aims to enhance the tool’s accuracy by adding new RNAseq data from the Hartwig Medical Foundation.

Sarah Watson, Institut Curie, France