DR-450 Identifying mechanisms for the ubiquitous differential gene expressions in homologous recombination deficient tumours

This project investigates why tumors with homologous recombination deficiency (HRD), a specific type of impaired DNA damage repair, show widespread changes in gene activity. By analysing genomic and gene expression data from cancer patients, we aim to uncover mechanisms behind these changes. This research could improve how HRD tumors are identified, lead to better diagnostic tools, and potentially reveal new treatment targets. While breast cancer is a primary focus, we will also explore HRD patterns in other cancer types, enhancing our understanding and clinical approaches across cancers.

Sabine Linn, Netherlands Cancer Institute, the Netherlands