DR-490 Detection of DNA damage response (DDR) dysfunction from tumor sequencing data

To continue unchecked growth, cancer cells bypass mechanisms that protect our genomic code, such as DNA repair and telomere maintenance. We will use tumor sequencing data from large patient cohorts, including from the Hartwig Medical Foundation (HMF), to characterize defects in genome maintenance mechanisms, and study how these changes influence treatment response and tumor prognosis. This work will enable clinicians to use clinical sequencing of patients’ genomes to guide treatment decisions and may reveal new therapeutic targets.

Quaid Morris, Memorial Sloan Kettering Cancer Center, United States