DR-220 An exploratory study on genomic correlates of anti-tumour immunity in castration-resistant prostate cancer.

Checkpoint inhibitors have failed to demonstrate a survival benefit in unselected castration-resistant prostate cancer (CRPC) patients. Nevertheless, biochemical and radiographic responses have been observed in a subset of trial participants. Here, we will study the association between immune signatures, genomic aberrations and clinical outcome to identify more immunogenic subgroups. A better understanding of factors that influence the immune infiltrate can help to select subgroups for checkpoint inhibitors and might serve as starting point for other immune-based therapies in prostate cancer.

Niven Mehra Radboudumc the Netherlands