DR-140 Landscape of cooperative interactions between germline and somatic events in cancer

In this project we will investigate to what extent the cooperation of inherited polymorphisms within regulatory regions and somatic aberration patterns affects evolution of cancer by altering oncogenic signalling pathways and promoting disease progression. Whole Genome Sequencing (WGS) data of metastatic cancer patients (tissue and matched control) will be analysed and compared/integrated to data from other sources (PCAWG, GTeX and ENCODE). This project will lead to the identification of germline biomarkers capable to announce the emergence of specific cancer subtypes and driver cancer aberration patterns, hence help stratifying patients with potential aggressive progression.

Alessandro Romanel University of Trento Italy