DR-125 Characterizing genome instability profiles in human cancers

We aim to understand the molecular mechanisms leading to the high degree of mutability observed in certain types of tumors and to clarify how these same mechanisms can influence tumor evolution and therapeutic response, with the ultimate goal to effectively tailor treatment to each individual tumor patient. We will use the Hartwig Medical Foundation (HMF) WGS cancer dataset to compare the type, number and genomic distribution of somatic mutations across different tumor subtypes, ultimately gaining insights into the precise factors that lead to tumor initiation, growth and evolution.

Edison Liu The Jackson Laboratory USA