DR-045 DR-009 extension: Lung and melanoma genomic profiles

Immunotherapies stimulate the patients own immune system to kill tumor cells. These relatively new therapies have shown impressive treatment results in many different tumor types. However, these impressive responses are restricted to only a subset of patients; many patients do not have benefit from these treatments, as the tumors keep growing and the patients suffer from treatment side-effects. We set up an ongoing project in which we try to understand why particular patients are not responding based on their DNA. If we understand this, we could (1) prevent treatment of patients with tumors resistant to immunotherapy and (2) develop strategies to overcome such resistance.

Emile Voest NKI/AvL the Netherlands