DR-062 The genetic profile of malignant pleural mesothelioma (MPM) and response to therapy

Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that arises from the mesothelial surfaces of the pleural cavity. Currently no curative treatment options are available. Recently, promising new treatment options have emerged, including immune checkpoint inhibitors and cell based vaccines. In order to give the best therapy to each patient, a better understanding of the tumor cells and their interaction with their microenvionment is necessary. We would like to investigate how abberations in the genetic material of the tumor can lead to the development, maintenance and progression of the tumor and how different therapies can influence these processes.

Joachim Aerts Erasmus MC the Netherlands