DR-068 The integration of genomics and transcriptomics using biopsies of metastatic breast cancer patients

Breast cancer is the most common malignancy among women wordwide. To reveal the genomic landscape of metastatic breast cancer, we recently performed an extensive genomic analysis which provided important novel insights into the biology of metastatic breast cancer and identified clinically relevant subgroups of patients who might benefit in the future from specific therapies. With this project we aim to correlate the findings on the DNA level with data generated from RNA. This will lead to increased knowledge of metastatic breast cancer and probably provides new predictive and prognostic information by integrating these two data sources. Finally, our goal is to improve personalized cancer treatment for patients with metastatic breast cancer.

John Martens Erasmus MC the Netherlands