DR-076 Whole genome Sequencing to estimate TEmozolomide Associated Response IN Gliomas (STEARING)

Breast cancer is the most common cancer among women Worldwide. Inherited variants in breast cancer susceptibility genes or other regions in the genome that increase breast cancer risk play an important role in the development of breast cancer. These germline genetic variants facilitate the establishment of risk prediction models for women. Furthermore, understanding of the mechanisms by which these genetic variants cause the development of breast cancer is important to devise novel prevention and treatment strategies for women who carry these variants. Here we aim to discover novel germline genetic variants and the features associated with currently known variants.

John Martens, NKI/AvL,Marjanka Schmidt, Erasmus MC NKI/AvL / Erasmus MC the Netherlands