DR-096 Cisplatin exposure related genomic changes in human germ cell tumors

The nature and impact of genomic changes induced by cisplatin treatment of germ cell tumors is unknown. This is relevant to identify mechanisms of treatment sensitivity and resistance. Genomic data on metastatic germ cell tumors will be compared with primary (non-metastasized) cases, supported by cell line-based observations. Recent data demonstrate that heterogeneity exist in the genomic constitution of primary human germ cell tumors before chemotherapy treatment. Selection of a defined subclone is likely related to treatment resistance, which might help to identify the mechanism involved, being the basis for development of alternatve treatment strategies.

Laurens van der Vlier Princes Maxima Centrum the Netherlands