DR-097 Molecular mechanisms of interplay between DNA repair pathways in chemotherapy resistance

The main purpose of the research project is to understand the mechanism of interplay between DNA repair pathways associated with acquired chemotherapy resistance. We will download the genomes of ovary cancer patients from the Hartwig Medical Foundation and perform whole-genome sequencing data analyses with particular emphasis on the assessment of DNA repair pathways and its correlation with clinical outcomes. This data mining will reveal the genetic differences between sensitive and resistant tumors and a dominant mechanism that provides the resistance in clinics.

Paweł Zawadzki Adam Mickiewicz University Poland