DR-115 The association between the homozygous germline deletion of chromosome 8 (ADAM3A region) and survival of patients with the tumours of digestive system treated with different regimens.

Oesophageal adenocarcinoma (EAC) is an aggressive cancer with a poor overall prognosis. Our data from shallow sequencing of 95 patients with EAC show a worse prognosis in patients who present a homozygous germline deletion of ADAM3A gene, treated with chemoradiotherapy according to CROSS schema. Approximately 20% of the European population shows deletion in this region, however the frequency and consequences of this deletion are not yet well characterised in patients with cancer, in general. The aim of this data request is to investigate the association of ADAM3A germline and somatic deletions in patients with metastatic cancer and to elucidate the role of this deletion in prediction of clinical outcome in patients treated with different chemo(radiation) regimens.

Liudmila Kodach NKI-AvL the Netherlands