DR-134 The immunogenic potential of recurrent cancer drug resistance mutations: an in silico study

Targeted cancer therapies can be remarkably effective but a considerable number of patients develop resistance as treatment proceeds. Resistance can be caused by specific mutations in cancer cells. Using computational analysis we have shown that a significant fraction of these resistance mutations are predicted to have immunogenic potential across a large proportion of the healthy human population. We intend to use the Hartwig Medical Database to verify if this holds true also in a patients’ population. If immunogenic in patients, recurrent resistance mutations could be extremely interesting in the context of off-the-shelf precision immunotherapies such as therapeutic cancer vaccines.

Stefano Lise The Institute of Cancer Research United Kingdom